Promethazine is an H1 receptor blocking agent. Together with its antihistaminic action, it offers clinically handy sedative and antiemetic outcomes.
Promethazine HCl and Codeine Phosphate Oral Alternative ought to be applied with caution in individuals with impairment of hepatic perform, and people ought to be monitored closely for respiratory depression, sedation, and hypotension.
Codeine: In clients obtaining MAO inhibitors, an initial compact test dose is highly recommended to allow observation of any too much narcotic outcomes or MAOI interaction.
Warning should be exercised when promethazine hydrochloride and codeine phosphate syrup is administered to the nursing lady.
Promethazine: Promethazine can be a phenothiazine by-product which differs structurally from the antipsychotic phenothiazines because of the presence of a branched facet chain and no ring substitution.
Promethazine Carcinogenicity studies have been conducted with promethazine hydrochloride. Two-year research in F344/N rats and B6C3F1 mice ended up done to evaluate the carcinogenic potential of promethazine hydrochloride. No proof of tumorigenicity was noticed in male and woman rats at promethazine hydrochloride oral doses up to 33 mg/kg/day for five times/week (around such as 10 occasions the MRHD on the mg/m2 foundation).
For preoperative medication, kids have to have doses of 0.five mg for every pound of overall body body weight together with the properly lowered dose of narcotic or barbiturate and the right dose of an atropine-like drug.
Excessively significant dosages of antihistamines, which include Promethazine HCl Oral Option, in pediatric sufferers may perhaps result in sudden death (see OVERDOSAGE). Hallucinations and convulsions have happened with therapeutic doses and overdoses of Promethazine in pediatric sufferers. In pediatric patients who will be acutely sick affiliated with dehydration, There may be an increased susceptibility to dystonias with the use of Promethazine HCl.
Promethazine HCl Oral Resolution is contraindicated in comatose states, and in individuals recognized to become hypersensitive or to get experienced an idiosyncratic reaction to Promethazine or to other phenothiazines.
It truly is soluble in water and freely soluble in alcohol. It's a molecular excess weight of 320.88, a molecular system of C17H20N2S•HCl, and the subsequent structural method:
Postmarketing cases of respiratory melancholy, which include fatalities, happen to be claimed with usage of promethazine hydrochloride in pediatric people below two yrs of age. A wide range of bodyweight-based mostly doses of promethazine hydrochloride have resulted in respiratory melancholy in these people.
The diagnostic analysis of clients with this syndrome is complicated. In arriving in a prognosis, it is important to detect situations where the scientific presentation consists of each really serious professional medical health get more info issues (e.
Promethazine hydrochloride and codeine phosphate syrup is indicated for your short-term reduction of coughs and higher respiratory indicators connected to allergy or the popular chilly.
The codeine and promethazine in Promethazine HCl and Codeine Phosphate Oral Answer could enhance the frequency of seizures in patients with seizure Issues, and could raise the danger of seizures developing in other medical settings related to seizures.